Additive Effects of Mechanical Marrow Ablation and PTH Treatment on de Novo Bone Formation in Mature Adult Rats
Identifieur interne : 001337 ( Main/Exploration ); précédent : 001336; suivant : 001338Additive Effects of Mechanical Marrow Ablation and PTH Treatment on de Novo Bone Formation in Mature Adult Rats
Auteurs : Qing Zhang [États-Unis] ; Christopher Miller ; Jesse Bible ; Jiliang Li ; Xiaoqing Xu [États-Unis] ; Nozer Mehta ; James Gilligan ; Agnès Vignery [États-Unis] ; Jodi A Carlson Scholz [États-Unis]Source :
- Cells [ 2073-4409 ] ; 2012.
Abstract
Mechanical ablation of bone marrow in young rats induces rapid but transient bone growth, which can be enhanced and maintained for three weeks by the administration of parathyroid hormone (PTH). Additionally, marrow ablation, followed by PTH treatment for three months leads to increased cortical thickness. In this study, we sought to determine whether PTH enhances bone formation after marrow ablation in aged rats. Aged rats underwent unilateral femoral marrow ablation and treatment with PTH or vehicle for four weeks. Both femurs from each rat were analyzed by X-ray and pQCT, then analyzed either by microCT, histology or biomechanical testing. Marrow ablation alone induced transient bone formation of low abundance that persisted over four weeks, while marrow ablation followed by PTH induced bone formation of high abundance that also persisted over four weeks. Our data confirms that the osteo-inducive effect of marrow ablation and the additive effect of marrow ablation, followed by PTH, occurs in aged rats. Our observations open new avenues of investigations in the field of tissue regeneration. Local marrow ablation, in conjunction with an anabolic agent, might provide a new platform for rapid site-directed bone growth in areas of high bone loss, such as in the hip and wrist, which are subject to fracture.
Url:
DOI: 10.3390/cells1041168
PubMed: 24710549
PubMed Central: 3901151
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Additive Effects of Mechanical Marrow Ablation and PTH Treatment on <italic>de Novo</italic> Bone Formation in Mature Adult Rats </title><author><name sortKey="Zhang, Qing" sort="Zhang, Qing" uniqKey="Zhang Q" first="Qing" last="Zhang">Qing Zhang</name><affiliation><nlm:aff id="af1-cells-01-01168">Department of Orthopaedics, Yale University School of Medicine, 310 Cedar Street, New Haven 06510, CT, USA; E-Mails:<email>qing.zhang@yale.edu</email> (Q.Z.);<email>xqing011@yahoo.com</email> (X.X.);<email>agnes.vignery@yale.edu</email> (A.V.)</nlm:aff></affiliation><affiliation wicri:level="2"><nlm:aff id="af2-cells-01-01168">Department of Cell Biology, Yale University School of Medicine, 310 Cedar Street, New Haven 06510, CT, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Cell Biology, Yale University School of Medicine, 310 Cedar Street, New Haven 06510, CT</wicri:regionArea><placeName><region type="state">Connecticut</region></placeName></affiliation></author><author><name sortKey="Miller, Christopher" sort="Miller, Christopher" uniqKey="Miller C" first="Christopher" last="Miller">Christopher Miller</name><affiliation><nlm:aff id="af3-cells-01-01168">Department of Orthopaedics and Rehabilitation, Yale University School of Medicine, 310 Cedar Street, New Haven 06510, CT, USA; E-Mails:<email>christopher.p.miller@yale.edu</email> (C.M.);<email>jesse.bible@yale.edu</email> (J.B.)</nlm:aff></affiliation></author><author><name sortKey="Bible, Jesse" sort="Bible, Jesse" uniqKey="Bible J" first="Jesse" last="Bible">Jesse Bible</name><affiliation><nlm:aff id="af3-cells-01-01168">Department of Orthopaedics and Rehabilitation, Yale University School of Medicine, 310 Cedar Street, New Haven 06510, CT, USA; E-Mails:<email>christopher.p.miller@yale.edu</email> (C.M.);<email>jesse.bible@yale.edu</email> (J.B.)</nlm:aff></affiliation></author><author><name sortKey="Li, Jiliang" sort="Li, Jiliang" uniqKey="Li J" first="Jiliang" last="Li">Jiliang Li</name><affiliation><nlm:aff id="af4-cells-01-01168">Department of Biology, Indiana University Purdue University Indianapolis, 723 West Michigan Street, SL306, Indianapolis 46202, IN, USA; E-Mail:<email>jilili@iupui.edu</email></nlm:aff></affiliation></author><author><name sortKey="Xu, Xiaoqing" sort="Xu, Xiaoqing" uniqKey="Xu X" first="Xiaoqing" last="Xu">Xiaoqing Xu</name><affiliation><nlm:aff id="af1-cells-01-01168">Department of Orthopaedics, Yale University School of Medicine, 310 Cedar Street, New Haven 06510, CT, USA; E-Mails:<email>qing.zhang@yale.edu</email> (Q.Z.);<email>xqing011@yahoo.com</email> (X.X.);<email>agnes.vignery@yale.edu</email> (A.V.)</nlm:aff></affiliation><affiliation wicri:level="2"><nlm:aff id="af2-cells-01-01168">Department of Cell Biology, Yale University School of Medicine, 310 Cedar Street, New Haven 06510, CT, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Cell Biology, Yale University School of Medicine, 310 Cedar Street, New Haven 06510, CT</wicri:regionArea><placeName><region type="state">Connecticut</region></placeName></affiliation></author><author><name sortKey="Mehta, Nozer" sort="Mehta, Nozer" uniqKey="Mehta N" first="Nozer" last="Mehta">Nozer Mehta</name><affiliation><nlm:aff id="af5-cells-01-01168">Unigene Laboratories, Inc. 81 Fulton Street, Boonton 07005, NJ, USA; E-Mails:<email>nmehta@unigene.com</email> (N.M.);<email>JGilligan@tarsatherapeutics.com</email> (J.G.)</nlm:aff></affiliation></author><author><name sortKey="Gilligan, James" sort="Gilligan, James" uniqKey="Gilligan J" first="James" last="Gilligan">James Gilligan</name><affiliation><nlm:aff id="af5-cells-01-01168">Unigene Laboratories, Inc. 81 Fulton Street, Boonton 07005, NJ, USA; E-Mails:<email>nmehta@unigene.com</email> (N.M.);<email>JGilligan@tarsatherapeutics.com</email> (J.G.)</nlm:aff></affiliation></author><author><name sortKey="Vignery, Agnes" sort="Vignery, Agnes" uniqKey="Vignery A" first="Agnès" last="Vignery">Agnès Vignery</name><affiliation><nlm:aff id="af1-cells-01-01168">Department of Orthopaedics, Yale University School of Medicine, 310 Cedar Street, New Haven 06510, CT, USA; E-Mails:<email>qing.zhang@yale.edu</email> (Q.Z.);<email>xqing011@yahoo.com</email> (X.X.);<email>agnes.vignery@yale.edu</email> (A.V.)</nlm:aff></affiliation><affiliation wicri:level="2"><nlm:aff id="af2-cells-01-01168">Department of Cell Biology, Yale University School of Medicine, 310 Cedar Street, New Haven 06510, CT, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Cell Biology, Yale University School of Medicine, 310 Cedar Street, New Haven 06510, CT</wicri:regionArea><placeName><region type="state">Connecticut</region></placeName></affiliation></author><author><name sortKey="Scholz, Jodi A Carlson" sort="Scholz, Jodi A Carlson" uniqKey="Scholz J" first="Jodi A Carlson" last="Scholz">Jodi A Carlson Scholz</name><affiliation wicri:level="2"><nlm:aff id="af6-cells-01-01168">Section of Comparative Medicine, Yale University School of Medicine, 310 Cedar Street, New Haven 06510, CT, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Section of Comparative Medicine, Yale University School of Medicine, 310 Cedar Street, New Haven 06510, CT</wicri:regionArea><placeName><region type="state">Connecticut</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">24710549</idno><idno type="pmc">3901151</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3901151</idno><idno type="RBID">PMC:3901151</idno><idno type="doi">10.3390/cells1041168</idno><date when="2012">2012</date><idno type="wicri:Area/Pmc/Corpus">000830</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000830</idno><idno type="wicri:Area/Pmc/Curation">000830</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000830</idno><idno type="wicri:Area/Pmc/Checkpoint">000770</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000770</idno><idno type="wicri:Area/Ncbi/Merge">000435</idno><idno type="wicri:Area/Ncbi/Curation">000435</idno><idno type="wicri:Area/Ncbi/Checkpoint">000435</idno><idno type="wicri:Area/Main/Merge">001339</idno><idno type="wicri:Area/Main/Curation">001337</idno><idno type="wicri:Area/Main/Exploration">001337</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Additive Effects of Mechanical Marrow Ablation and PTH Treatment on <italic>de Novo</italic> Bone Formation in Mature Adult Rats </title><author><name sortKey="Zhang, Qing" sort="Zhang, Qing" uniqKey="Zhang Q" first="Qing" last="Zhang">Qing Zhang</name><affiliation><nlm:aff id="af1-cells-01-01168">Department of Orthopaedics, Yale University School of Medicine, 310 Cedar Street, New Haven 06510, CT, USA; E-Mails:<email>qing.zhang@yale.edu</email> (Q.Z.);<email>xqing011@yahoo.com</email> (X.X.);<email>agnes.vignery@yale.edu</email> (A.V.)</nlm:aff></affiliation><affiliation wicri:level="2"><nlm:aff id="af2-cells-01-01168">Department of Cell Biology, Yale University School of Medicine, 310 Cedar Street, New Haven 06510, CT, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Cell Biology, Yale University School of Medicine, 310 Cedar Street, New Haven 06510, CT</wicri:regionArea><placeName><region type="state">Connecticut</region></placeName></affiliation></author><author><name sortKey="Miller, Christopher" sort="Miller, Christopher" uniqKey="Miller C" first="Christopher" last="Miller">Christopher Miller</name><affiliation><nlm:aff id="af3-cells-01-01168">Department of Orthopaedics and Rehabilitation, Yale University School of Medicine, 310 Cedar Street, New Haven 06510, CT, USA; E-Mails:<email>christopher.p.miller@yale.edu</email> (C.M.);<email>jesse.bible@yale.edu</email> (J.B.)</nlm:aff></affiliation></author><author><name sortKey="Bible, Jesse" sort="Bible, Jesse" uniqKey="Bible J" first="Jesse" last="Bible">Jesse Bible</name><affiliation><nlm:aff id="af3-cells-01-01168">Department of Orthopaedics and Rehabilitation, Yale University School of Medicine, 310 Cedar Street, New Haven 06510, CT, USA; E-Mails:<email>christopher.p.miller@yale.edu</email> (C.M.);<email>jesse.bible@yale.edu</email> (J.B.)</nlm:aff></affiliation></author><author><name sortKey="Li, Jiliang" sort="Li, Jiliang" uniqKey="Li J" first="Jiliang" last="Li">Jiliang Li</name><affiliation><nlm:aff id="af4-cells-01-01168">Department of Biology, Indiana University Purdue University Indianapolis, 723 West Michigan Street, SL306, Indianapolis 46202, IN, USA; E-Mail:<email>jilili@iupui.edu</email></nlm:aff></affiliation></author><author><name sortKey="Xu, Xiaoqing" sort="Xu, Xiaoqing" uniqKey="Xu X" first="Xiaoqing" last="Xu">Xiaoqing Xu</name><affiliation><nlm:aff id="af1-cells-01-01168">Department of Orthopaedics, Yale University School of Medicine, 310 Cedar Street, New Haven 06510, CT, USA; E-Mails:<email>qing.zhang@yale.edu</email> (Q.Z.);<email>xqing011@yahoo.com</email> (X.X.);<email>agnes.vignery@yale.edu</email> (A.V.)</nlm:aff></affiliation><affiliation wicri:level="2"><nlm:aff id="af2-cells-01-01168">Department of Cell Biology, Yale University School of Medicine, 310 Cedar Street, New Haven 06510, CT, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Cell Biology, Yale University School of Medicine, 310 Cedar Street, New Haven 06510, CT</wicri:regionArea><placeName><region type="state">Connecticut</region></placeName></affiliation></author><author><name sortKey="Mehta, Nozer" sort="Mehta, Nozer" uniqKey="Mehta N" first="Nozer" last="Mehta">Nozer Mehta</name><affiliation><nlm:aff id="af5-cells-01-01168">Unigene Laboratories, Inc. 81 Fulton Street, Boonton 07005, NJ, USA; E-Mails:<email>nmehta@unigene.com</email> (N.M.);<email>JGilligan@tarsatherapeutics.com</email> (J.G.)</nlm:aff></affiliation></author><author><name sortKey="Gilligan, James" sort="Gilligan, James" uniqKey="Gilligan J" first="James" last="Gilligan">James Gilligan</name><affiliation><nlm:aff id="af5-cells-01-01168">Unigene Laboratories, Inc. 81 Fulton Street, Boonton 07005, NJ, USA; E-Mails:<email>nmehta@unigene.com</email> (N.M.);<email>JGilligan@tarsatherapeutics.com</email> (J.G.)</nlm:aff></affiliation></author><author><name sortKey="Vignery, Agnes" sort="Vignery, Agnes" uniqKey="Vignery A" first="Agnès" last="Vignery">Agnès Vignery</name><affiliation><nlm:aff id="af1-cells-01-01168">Department of Orthopaedics, Yale University School of Medicine, 310 Cedar Street, New Haven 06510, CT, USA; E-Mails:<email>qing.zhang@yale.edu</email> (Q.Z.);<email>xqing011@yahoo.com</email> (X.X.);<email>agnes.vignery@yale.edu</email> (A.V.)</nlm:aff></affiliation><affiliation wicri:level="2"><nlm:aff id="af2-cells-01-01168">Department of Cell Biology, Yale University School of Medicine, 310 Cedar Street, New Haven 06510, CT, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Cell Biology, Yale University School of Medicine, 310 Cedar Street, New Haven 06510, CT</wicri:regionArea><placeName><region type="state">Connecticut</region></placeName></affiliation></author><author><name sortKey="Scholz, Jodi A Carlson" sort="Scholz, Jodi A Carlson" uniqKey="Scholz J" first="Jodi A Carlson" last="Scholz">Jodi A Carlson Scholz</name><affiliation wicri:level="2"><nlm:aff id="af6-cells-01-01168">Section of Comparative Medicine, Yale University School of Medicine, 310 Cedar Street, New Haven 06510, CT, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Section of Comparative Medicine, Yale University School of Medicine, 310 Cedar Street, New Haven 06510, CT</wicri:regionArea><placeName><region type="state">Connecticut</region></placeName></affiliation></author></analytic><series><title level="j">Cells</title><idno type="eISSN">2073-4409</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Mechanical ablation of bone marrow in young rats induces rapid but transient bone growth, which can be enhanced and maintained for three weeks by the administration of parathyroid hormone (PTH). Additionally, marrow ablation, followed by PTH treatment for three months leads to increased cortical thickness. In this study, we sought to determine whether PTH enhances bone formation after marrow ablation in aged rats. Aged rats underwent unilateral femoral marrow ablation and treatment with PTH or vehicle for four weeks. Both femurs from each rat were analyzed by X-ray and pQCT, then analyzed either by microCT, histology or biomechanical testing. Marrow ablation alone induced transient bone formation of low abundance that persisted over four weeks, while marrow ablation followed by PTH induced bone formation of high abundance that also persisted over four weeks. Our data confirms that the osteo-inducive effect of marrow ablation and the additive effect of marrow ablation, followed by PTH, occurs in aged rats. Our observations open new avenues of investigations in the field of tissue regeneration. Local marrow ablation, in conjunction with an anabolic agent, might provide a new platform for rapid site-directed bone growth in areas of high bone loss, such as in the hip and wrist, which are subject to fracture.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Reeve, J" uniqKey="Reeve J">J. Reeve</name></author><author><name sortKey="Hesp, R" uniqKey="Hesp R">R. Hesp</name></author><author><name sortKey="Williams, D" uniqKey="Williams D">D. Williams</name></author><author><name sortKey="Hulme, P" uniqKey="Hulme P">P. Hulme</name></author><author><name sortKey="Klenerman, L" uniqKey="Klenerman L">L. Klenerman</name></author><author><name sortKey="Zanelli, J M" uniqKey="Zanelli J">J.M. Zanelli</name></author><author><name sortKey="Darby, A J" uniqKey="Darby A">A.J. Darby</name></author><author><name sortKey="Tregear, G W" uniqKey="Tregear G">G.W. 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Sumner</name></author><author><name sortKey="Virdi, A S" uniqKey="Virdi A">A.S. Virdi</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Connecticut</li></region></list><tree><noCountry><name sortKey="Bible, Jesse" sort="Bible, Jesse" uniqKey="Bible J" first="Jesse" last="Bible">Jesse Bible</name><name sortKey="Gilligan, James" sort="Gilligan, James" uniqKey="Gilligan J" first="James" last="Gilligan">James Gilligan</name><name sortKey="Li, Jiliang" sort="Li, Jiliang" uniqKey="Li J" first="Jiliang" last="Li">Jiliang Li</name><name sortKey="Mehta, Nozer" sort="Mehta, Nozer" uniqKey="Mehta N" first="Nozer" last="Mehta">Nozer Mehta</name><name sortKey="Miller, Christopher" sort="Miller, Christopher" uniqKey="Miller C" first="Christopher" last="Miller">Christopher Miller</name></noCountry><country name="États-Unis"><region name="Connecticut"><name sortKey="Zhang, Qing" sort="Zhang, Qing" uniqKey="Zhang Q" first="Qing" last="Zhang">Qing Zhang</name></region><name sortKey="Scholz, Jodi A Carlson" sort="Scholz, Jodi A Carlson" uniqKey="Scholz J" first="Jodi A Carlson" last="Scholz">Jodi A Carlson Scholz</name><name sortKey="Vignery, Agnes" sort="Vignery, Agnes" uniqKey="Vignery A" first="Agnès" last="Vignery">Agnès Vignery</name><name sortKey="Xu, Xiaoqing" sort="Xu, Xiaoqing" uniqKey="Xu X" first="Xiaoqing" last="Xu">Xiaoqing Xu</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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